Signaling lymphocytic activation molecule

Chu CY, Chang CP, Chou YT, Handoko HYL, Lo LC, Lin JJ (2013) Development and evaluation of novel phosphotyrosine mimetic inhibitors targeting the Src homology 2 domain of signaling lymphocytic activation molecule (SLAM) associated protein. J Med Chem 56 2841-2849... 

The cells of the immune system communicate with each other particularly intensively. The T-cell receptor plays a central role in the activation of T lymphocytes (see p. 296). The cell at the top has been infected with a virus, and it indicates this by presenting a viral peptide (violet) with the help of a class 1 MHC protein (yellow and green). The combination of the two molecules is recognized by the dimeric T-cell receptor (blue) and converted into a signal that activates the T cell (bottom) and thereby enhances the immune response to the virus. 

FKBP12 is a member of immunophilin family that has prolyl isomerase activity and is related to the cyclophi-lins in function. FKBP12 binds immunosuppressant molecule FK506 (tacrolimus). The FBKP-FK506 complex inhibits calcineurin, a protein phosphatase, thus blocking signal transduction in the T-lymphocyte... 

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