Signaling in Neuronal Plasticity and Memory Formation

What is renovating in your brain right now as you are learning about signaling of memory formation, a fraction of which you will perhaps retain in your memory for years to come The answer is neuronal plasticity, the key prelude to memory formation. It is a consequence of both, qualitative alteration in efficacy of synaptic transmission and quantitative alteration in synapse number due to synaptic growth. 

Signaling in Generation of Short-Term Plasticity and Short-Term Memory 

Signaling in Generation of Long-Term Plasticity and Memory 

In addition to CREB, nuclear factor kappaB (NF-kB) is another architect of importance in facilitating long-term processes. NF-kB p50 p65 is located in synapses of neurons and is engaged in Ca + responsive pathway. Additionally, it has been proposed that activation of NF-kB p50 p65 is dependent on CaMKIl activation (Meffert and Baltimore, 2005). As suggested 

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Mazzucchelli, C. BrambiUa, R. (2000). Ras-related and MARK signalling in neuronal plasticity and memory formation. Cellular and Molecular Life Sciences, 57, 604—611. 

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