Signal sequence and translocation

Signal sequences and translocation. In 1971, Blobel and Sabatini postulated that for some proteins an N-terminal segment of newly synthesized polypeptide chains contains a signal sequence or leader peptide of 15-30 amino acids which carries information concerning the location of the mature protein in the cell.23 280 The rather nonpolar signal sequences of proteins destined for secretion from cells would interact... 

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