Sigler

TFIIA and TFIIB are two basal transcription factors that are involved in the nucleation stages of the preinitiation complex by binding to the TBP-TATA box complex. Crystal structures of the ternary complex TFIIA-TBP-TATA box have been determined by the groups of Paul Sigler, Yale University, and Timothy Richmond, ETH, Zurich, and that of the TFIIB-TBP-TATA box by Stephen Burley and collaborators. The TBP-DNA interactions and the distortions of the DNA structure are essentially the same in these ternary complexes as in the binary TBP-TATA complex. 

Matthews, B.W., Sigler, P.B., Henderson, R., Blow, D.M. Three-dimensional structure of tosyl-a-chymotrypsin. Nature 214 652-656, 1967. 

Sigler, P.B., et al. Structure of crystalline a-chymotrypsin II. A preliminary report including a hypothesis for the activation mechanism. /. Mol. Biol. 35 143-164, 1968. 

Bohm, A., Gaudet, R., Sigler, P.B. Structural aspects of het-erotrimeric G-protein signaling. Cun. Opin. Struct. Biol. 8 480-487, 1997. 

Noel, J.R, Hamm, H.E., Sigler, P.B. The 2.2 A crystal structure of transducin-a complexed with GTPyS. Nature 366 654-663, 1993. 

Observations, made by Sigler and Masters , on the exchange in 0.4 M H2SO4, solution, have led to a rate law... 

ROBERTSON D G, REILY M D, SIGLER R E et al, (2000) Metabonomics Evaluation of nuclear magnetic resonance (NMR) and pattern recognition technology for rapid in vivo screening of liver and kidney toxicants. Toxicol Sci. 57 326-37. 

The monograph on Malbranchae spp. by Sigler and Carmichael should be consulted for the identification of Scytalidium species and similar hyphomycetes that produce arthroconidia. 

Freedman LP, Luisi BF, Korszum ZR, Basavappa R, Sigler PB, Yamamoto KR (1988) The function and structure of the metal coordination sites within the glucorticoid receptor DNA binding domain. Nature 334 543... 

Lambright D, Sondek J, Bohm A, Skiba N, Hamm H, Sigler P (1996) Nature 379 311... 

Varoqueaux, F., Sigler, A., Rhee, J. S., Brose, N., Enk, C., Reim, K., and Rosenmund, C. (2002) Total arrest of spontaneous and evoked synaptic transmission but normal synapto-genesis in the absence of Muncl3-mediated vesicle priming. Proc. Natl. Acad. Sci. USA 99, 9037-9042. 

Yang, Y., Pesaro, M., Sigler, W., and Zeyer, J., 2005, Identification of microorganisms involved in reductive dehalogenation of chlorinated ethenes in an anaerobic microbial community. Water Res. 39 3954-3966. 

Sondek J, Bohm A, Lambright DG, Hamm HE, Sigler PB. 1996. Crystal structure of a G-protein Py dimer at 2.1 A resolution. Nature 379 369-374. 

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