Side effects genetic variations

The situation becomes somewhat more complicated if one considers the effects on genetic variation if more than one refugium had existed. Premoli et al. (2000) discussed two effects the Cordillera effect and the extent-of-the-ice effect. In the case of the Cordillera effect, the assumption was made that there was incomplete ice coverage, resulting in patches of forest remaining intact on either side of the Andes this amounts to the existence of multiple local refugia that would supply propagules... 

Commonly used drugs (other than isoniazid) affected by NAT2 polymorphism were procainamide, hydralazine, dapsone, and sulfonamides with an increase of side effects in all cases. A selective substrate of NATl is -aminosalicylic acid (PAS), but its genetic variation was never clinically important (52). Because of such lack of importance, more attention is often paid to the fact that various industrial chemicals with carcinogenic potential, and mutagenic heterocyclic amines, are substrates of both N-acetyltransferases (53). The presence or absence of these transferases will determine some incidences of cancer (54). Attempts have been made to ascribe cancer incidences in different populations to acetyltransferase differences (55). 

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