Siastatin, sialidase inhibitor

H. Umezawa, T. Aoyagi, T. Komiyama, H. Morishima, M. Hamada, and T. Takeuchi, Purification and characterization of a sialidase inhibitor, siastatin, produced by Streptomyces, J. Antibiot., 27 (1974) 963-969. 

In order to clarify its absolute stereochemistiy, both enantiomers of the naturally-occurring sialidase inhibitor siastatin B were prepared from the enantiomers of ribose in multistep sequences, and the natural product was shown to have structure (48), the carbons of the precursor L-ribose being indicated.Compounds (49, R=H and OBn) have been prepared from D-glucose (carbons indicated) as potential precursors for the pyrrolizidine alkaloids retroneclne and crotanecine respectlvely. S Some other references to the synthesis of hydroxylated pyrrolidines and piperidines appear in Chapter 18. 

The purification and characterization of siastatin, a sialidase inhibitor produced by a Streptomyces species, have been described. ... 

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