Sialidation Using 2-Thioglycosides, Xanthates, or Phosphites of Sialic Acids in Acetonitrile

4 Sialidation Using 2-Thioglycosides, Xanthates, or Phosphites of Sialic Acids in Acetonitrile 

The iV-acetoxyacetamido (40a) [17], iV-benzyloxyacetamido (40b) [18], and N-trifluoroacetamido (42) [19] derivatives of 15 or 16 were also successfully coupled 

Entry Donor Acceptor Promoter Product Isolated yield (%) a p  

NIS/TMSOTf. The yields and a-selectivity are quite appreciable, considering the bulkiness of the donor and the steric hindrance on the sialidation site. 

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