Sialidases Subject

IgG receptors on cultured, human lymphocytes.526 Sialidase treatment of lymphocytes from sensitized subjects increased the responsiveness to viral, bacterial, and fungal antigens.527 The same treatment of human, Herpes simplex virus-infected cells was found to enhance the sensitivity of the cells to lysis mediated by antibody and complement.528... 

Another class of potent and selective influenza virus sialidase inhibitors which are orally active against influenza A and B, based on a cyclopentane framework, have also been described [54], Although not yet commercially available, BCX-1812 (RWJ-270201,5) has been subjected to Phase III clinical trials. BCX-1812 (5) is a nanomolar inhibitor of both influenza virus A and B sialidase and inhibits growth of influenza virus in tissue culture [55] and has demonstrated efficacy in a mouse influenza model... 

Sialic acids as such, sialic acid derivatives, analogues, glycosides and sialo-oligosaccharides have been subject of many synthetic investigations. These studies were aimed at a further exploration of the properties of sialic acids, the preparation of substrates and inhibitors for sialidases, sialyltransferases or for sialic acid converting enzymes, and to make compounds accessable for analytical purposes or for studies related to metabolism or biological functions of sialic acids. 

The influence of the C-7 to C-9 side chain of the sialic acid molecule on sialidase action has been demonstrated using complex carbohydrates subjected to mild periodate oxidation and subsequent borohydride reduction to yield C-7 and C-8 analogues of sialic acid. The progressive shortening of the chain led to a progressive decrease in bacterial and viral sialidase action (Suttajit and Winzler... 

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