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Sialidase inhibitor constants

Antigenic determinants were found across the top surface of the sialidase monomer and encircling the active site [62], Of importance for inhibitor development, the active site was seen to contain a large number of amino acids that were conserved in all influenza A and B virus sialidase sequences known to that time [34,62]. This suggested that the active site residues were under pressure to remain constant [69], and that this was an invariant area of the sialidase that could be targeted for inhibitor development against the otherwise highly mutable [4] protein. [Pg.657]


See other pages where Sialidase inhibitor constants is mentioned: [Pg.118]    [Pg.209]    [Pg.347]    [Pg.740]    [Pg.278]    [Pg.736]    [Pg.224]    [Pg.209]    [Pg.148]   
See also in sourсe #XX -- [ Pg.344 ]




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