Sialic acids in gangliosides

Kisa F, Yamada K, Miyamoto T, Inagaki M, Fliguchi R (2007) Determination of the absolute configuration of sialic acids in gangliosides from the sea cucumber Cucumaria echinata. Chem Pharm Bull(Tokyo) 55 1051-1052... 

Reuter, G., and Schauer, R., 1987, Isolation and analysis of gangliosides with O-acetylated sialic acids, in Gangliosides and Modulation of Neuronal Functions, NATO ASI Series, Vol. H7 (H. Rahmann, ed.). Springer-Verlag, Berlin, pp. 155-165. 

Analysis of 3- and 6-linked sialic acids in mixtures of gangliosides separation of 62... 

C. Fahr and R. Schauer, Detection of sialic acids and gangliosides with special reference to 9-0-acetylated species in basilomas and normal human skin, J. Invest. Dermatol., 116 (2001) 254-260. 

Synthesis of sialic acid in the nervous system also exhibits a unique, control mechanism that may be delineated from the observation of an increased formation of sialic acid (ganglioside) in rat brain during training.242... 

Powell AK, Harvey DJ (1996) Stabilization of sialic acids in N-linked oligosaccharides and gangliosides for analysis by positive ion matrix-assisted laser desorption/ionization mass spectrometry. Rapid Commun Mass Spectrom 10 1027-1032... 

Ganglioside Sphingolipid with one or more sialic acids in the oligosaccharide headgroup. 

Glycosphingolipids that contain the sugar sialic acid in the carbohydrate portion are called gangliosides. 

Gangliosides appear to be confined to the animal kingdom. In man, cattle, horse, main ganglioside outside brain is Lactl A -Glycolyl-neuraminic acid is chief sialic acid in erythrocyte and spleen ganglioside of horse and cattle. 

Exo-a-sialidase (EC 3.2.1.18). Enzyme hydrolyses a-23, a-2,6- and a-2,8-glycosidic linkages of terminal sialic acid residues, Gangliosides, glycotipids, lipofus-cin and lysobisphosphatidic add accumulate in lysosomes of many tissues. Corneal opadties Dementia. No skeletal effects No hepatome y. 

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