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Sialic acid biological significance

W. Reutier, E. Kottgen, C. Bauer, and W. Gerok, Biological significance of sialic acid, in Sialic Acids. Chemistry, Metabolism, and Function, R. Schauer, ed., Springer-Verlag, Vienna, 1982, p. 263. [Pg.197]

Undoubtedly, the most critical area of the sialic acid structure for biological activity is the C-2 centre, which is involved in glycosidic linkages and is substituted with the C-1 carboxylic acid group. 2-Deoxy derivatives are of biological interest [4,103], in particular the 2-deoxy-2,3-didehydro derivatives, which show significant inhibitory activity against sialidases [4,156-158]. [Pg.145]

Reutter W, Kottgen E, Bauer C, Gerok W (1982) Biological significance of sialic acids. In Schauer R (ed) Sialic acids - Chemistry, metabolism and function. Springer, Berlin Heidelberg New York, p 263... [Pg.163]

Sialic acids typically present as terminal residues on glycoproteins and glycolipids are known to play a significant role in the mediation of many biological phenomena involving cell-cell and cell-matrix interactions by either reacting with specific surface receptors or masking other carbohydrate recc kion sites. ... [Pg.92]

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