Sherlock

The threshold dose of MDMA is 30 mg, but the average dose is 80-150 mg, with some users taking in excess of 200 mg. The lethal dose is estimated (from animal data) to be approximately 6,000 mg. On the street, concentrations of MDMA can vary greatly, and tablets may also contain other substances such as methylenedioxyamphetamine (MDA) and methylenedioxy-ethylamphetamine (MDEA) (Sherlock et al. 1999). The presence of these other substances is often associated with emergency presentations because of their narrower therapeutic windows. 

SharmaAN, Lombardi MH, Illuzzi FA, et al Management of gamma-hydroxybutyrate withdrawal. Ann Emerg Med 38 603-607, 2001 Sherlock K, Wolff K, Hay AW, et al Analysis of illicit ecstasy tablets implications for clinical management in the accident and emergency department. Emerg Med J 16 194-197, 1999... 

Indeed, whenever you focus your attention on any of the so-called intelligent systems, and you take the time to leam the mechanisms they use to generate their marvelous and wondrous behavior, you come up with the anti-climactic realization that everything is quite ordinary and perfectly expectable with no surprises or mystical insights. Such reaction reminds us of how Sherlock Holmes reacted when a man questioned the brilliance of his deductive reasoning in solving one of his cases ... 

Emissions of CH4 due to manure storage, which are fimctions of sforage time and temperature, averaged 4.5 kg CH4 m with slurry storage twice that of stacked storage (Chianese et ah, 2009a). Manure applied to cropland also provides a source of CH4 emissions but typically disappears after a few days (Sherlock et ah, 2002). 

It ll be lovely to see you, said my cousin Izzy on the phone two weeks ago when, late one evening and two whiskies down, I finally decided to do it, that there was no reason to delay. When we bought the house in Narrow Street, it wasn t a Queen Anne Residence Convenient for the City it was a tenement, in a slum. You could almost smell Sherlock Holmes s opium dens, see the lascars and hear the drunken sailors. Not anymore. There s every... 

Numerous observations of non-linear relationships between PbB concentration and lead intake in humans provide further support for the existence of a saturable absorption mechanism or some other capacity limited process in the distribution of lead in humans (Pocock et al. 1983 Sherlock et al. 1984, 1986). However, in immature swine that received oral doses of lead in soil, lead dose-blood lead relationships were non-linear whereas, dose-tissue lead relationships for bone, kidney and liver were linear. The same pattern (nonlinearity for PbB and linearity for tissues) was observed in swine administered lead acetate intravenously (Casteel et al. 1997). These results suggest that the non-linearity in the lead dose-PbB relationship may derive from an effect of lead dose on some aspect of the biokinetics of lead other than absorption. Evidence from mechanistic studies for capacity-limited processes at the level of the intestinal epithelium is compelling, which would suggest that the intake-uptake relationship for lead is likely to be non-linear these studies are discussed in greater detail in Section 2.4.1. 

Adult Females N=114 0.03 Duplicate diet study Ayr, Scotland EPA analysis Sherlock et al. 1982... 

Slope factors for the blood lead contribution from diet in adults can be obtained from an experimental study (Cools et al. 1976) and a duplicate diet study (Sherlock et al. 1982). These slope factors range from 0.027 to 0.034 pg/dL blood per pg lead intake/day (EPA 1986a). The data from the duplicate diet infant study by Ryu et al. (1983) were reanalyzed to derive a slope factor of 0.24 pg/dL blood per pg/day lead intake (EPA 1990e). 

Shea EE. 1996. Lead regulation handbook. Rockville, MD Government Institutes, 240 pages. Sherlock JC. 1987. Lead in food and the diet. Environmental Geochemistry and Health 9 43-47. 

Sherlock JC, Ashby D, Delves HT, et al. 1984. Reduction in exposure to lead from drinking water and its effect on blood lead concentrations. Human Toxicol 3 383-392. 

Sherlock JC, Quinn MJ. 1986. Relationship between blood and lead concentrations and dietary lead intake in infants The Glasgow Duplicate Diet Study 1979-1980. Food Addit Contam 3 167-176. 

Sherlock JC, Smart G, Forbes GI, et al. 1982. Assessment of lead intakes and dose-response for a population in Ayr exposed to a plumbosolvent water supply. Human Toxicol 1 115-122. 

Smart GA, Pickford CJ, Sherlock JC. 1990. Lead in alcoholic beverages A second survey. Food Addit Contain 7 93-99. 

Spellman, P. T., Sherlock, G., Zhang, M. Q., Iyer, V. R., Anders, K., Eisen, M. B., Brown, P. O., Bot-stein, D. and Futcher, B. (1998), Comprehensive identification of cell cycle-regulated genes of the yeast Saccharomyces cerevisiae by microarray hybridization , Mol Biol. Cell, 9, 3273-3297. 

---