Sheet hydrogel

With sheet hydrogel, the hydrophilic polymers, typically polyacrylamide or polyethylene oxide, are partially cross-linked to form a membrane with sufficient water-holding hydrophilic sites. Typically a hydrogel contains about 96% water. When applied to wound sites such as dermabrasions, minor bums, and skin donor sites, they relieve pain and reduce trauma on both application and removal of the dressings. Hydrogels can be dried to form a dehydrated hydrogel, which has a higher absorption capacity than the hydrated form. 

Fig. 11. Hydrogel process. Process flow sheet for the manufacture of 2eobtes 4A, 13X, and Y from reactant hydrogels (1).

Hydrogels Based on [l-Sheet Structures of Peptides and Polypeptides. 146... 

Smith AM, Williams RJ, Tang C et al (2008) Fmoc-diphenylalanine self assembles to a hydrogel via a novel architecture based on pi-pi interlocked beta-sheets. Adv Mater 20 37-41... 

Jeong and coworkers have reported peptide-based thermo-gelling systems using PEG-b-polyAla as an injectable cellular scaffold [315]. The polymer aqueous solution undergoes sol-gel transition as temperature increases. The fraction of the p-sheet structure of the poly Ala dictated the population and thickness of fibrous nanostructure in the hydrogel, which affected the proliferation and protein... 

AggeU A, BeU M, Boden N, Camck LM, Strong AE. Self-assembling peptide polyelectrol3de beta-sheet complexes form nematic hydrogels. Angew Chem Int Ed 2003 42 5603-5606. 

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