Shear stress leukocyte response

Its formation in vascular endothelial cells, in response to chemical stimuli and to physical stimuli such as shear stress, maintains a vasodilator tone that is essential for the regulation of blood flow and pressure. NO also inhibits platelet aggregation and adhesion, inhibits leukocyte adhesion and modulates smooth muscle cell proliferation. NO is also synthesized in neurons of the central nervous system (CNS), where it acts as a neuromediator with many physiological functions, including the formation of memory, coordination between neuronal activity and blood flow, and modulation of pain. In the peripheral nervous system, NO is now known to be the mediator released by a widespread network of nerves. ... 

Alteration of Polymorphonuclear Neutrophil Leukocyte Response to Shear Stress Exposure In Vitro Effects of Prostaglandin Ei and Dipyridamole Derivative RA-233... 

STOCK WELL ET AL. Leukocyte Response to Shear Stress... 

Earlier work in this laboratory and others demonstrated in vitro dysfunction of both platelets and leukocytes following application of low-level shear stress (1 4). The effects of mechanical trauma can be attributed to bulk shear stress effects rather than surface-mediated ones, since changing the surface-to-volume ratio by a factor of three did not alter the leukocyte or platelet response to a given shear stress intensity and exposure duration (2). Platelet microaggregate formation and adhesion alterations occurred following shear stress exposure in the range of 150 dyn/cm2 for 2 min, while... 

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