Sharpe, Richard

I am especially grateful to Richard Sharpe for his constructive comments on this article. I would also like to thank Philippa Saunders, John Sumpter, Jane Fisher and Stewart Irvine for their helpful discussions and for allowing me to include some of their unpublished data. Thanks to Ted Pinner for help with the figures. This work was supported by a Zeneca Strategic Research Fund Award. 

Biological evaluation of our synthetic A-Factor confirmed its activity we thank Dr. Richard Monaghan and his group at Merck Sharp and Dohme Research Labs for performing these tests. 

Hajos, M., Richards, C. D., Szekely, A. D. Sharp, T. (1998). An electrophysiological and neuroanatomical study of the medial prefrontal cortical projection to the midbrain raphe nuclei in the rat. Neuroscience 87, 95 108. 

The debate intensified recently with the publication of Richards et al. (2003), which claimed that, in Britain at least, on the evidence of bone collagen < 13, the transition from the Mesolithic to Neolithic (c. 4000 cal. bc) was a sharp one, with a complete abandonment of marine resources in the Neolithic, even by coastal communities (Fig. 8.10). This was further interpreted as being the result of a very rapid adoption of the Neolithic lifestyle of plant and animal domestication, contrary to earlier views which argued for a gradual shift. Perhaps predictably, this has provoked a sharp debate focusing on both the interpretation of isotopic evidence (Milner et al. 2003) and on evidence to the contrary for other parts of Europe (Liden et al. 2003). Milner et al. (2003) summarize the assumptions upon which the... 

Figure 8.10 Carbon isotope ratios in bone collagen plotted against radiocarbon ages for 183 British Mesolithic and Neolithic humans from coastal (within 10 km of modern coastline squares) and inland sites (crosses). The sharp change in carbon isotope ratio at around 5200 radiocarbon years BP is interpreted as a shift from a marine diet to one dominated by terrestrial protein. This coincides with the onset of the Neolithic period in Britain. (Reproduced from Richards et al. 2003, with permission of Nature Publishing Group and the first author.)...

Curran, S., Mill, J., Tahir, E., Kent, L., Richards, S., Gould, A., Huckett, L., Sharp, J., Batten, C., Fernando, S., Ozbay, F., Yaz-gan, Y., Simonoff, E., Thompson, M., Taylor, E., and Asherson, P. (2001) Association study of a dopamine transporter polymorphism and attention deficit hyperactivity disorder in UK and Turkish samples. Mol Psychiatry 6 425-428. 

Phillip Sharp and Richard Roberts independently discovered that many genes for polypeptides in eukaryotes are interrupted by noncoding sequences (nitrons). 

Richard J. Roberts and Phillip A. Sharp Physiology/Medicine Discovery of split genes... 

This is further confirmation that there is scope for constant selectivity regimes. Richard comments that the sharp dependence of selectivity upon reactivity he and McClelland found for relatively reactive cations must be moderated for more strongly stabilized ions if a limiting value of /3nuc near to 1.0 is not to be exceeded. As Richard points out, the low reactivity and high intrinsic barriers for highly stabilized electrophiles will necessarily be... 

An important feature of gel electrophoresis is that diffusion is restricted in the matrix, and remarkably sharp zones are consequently obtained. This is discussed in a paper by Richards and Lecanidou (1971), which should be consulted for a quantitative treatment. 

Since both these transport processes depend on the frictional coefficient of the molecule in the same way, this is a very reasonable assumption, and explains why under conditions of severe retardation zones remain extremely sharp. By application of Pick s laws, Richards and Lecanidou determine the evolution of the zone half-width with time, and derive the important result, confirmed by experiment, that the zone-width, provided the ratio of diffusion coefficient to retardation factor is of the right order, depends to only a slight extent on the width of the starting zone applied at one end of the gel. For typical conditions there is no detectable loss in resolution for an initial zone width of up to 2 mm, and even for a 1 cm column of RNA solution applied to the gel there is only a 25% increase in band width. 

This article is a revision of the previous print edition article by AJ Nordone, DE Sharp, and Richard A Parent, volume 2, pp. 40-41, 1998, Elsevier Inc. 

Richards AM, Doughty R, Nicholls MG, MacMahon S, Sharpe N, Murphy J, et al. Plasma N-terminal probrain natriuretic peptide and adrenomeduUin prognostic uthity and prediction of benefit from carvedilol in chronic ischemic left ventricular dysfunction. Austraha-New Zealand Heart Failure Group. J Am Coll Cardiol 2001 37 1781-7. 

Fig. 1-1 The electromagnetic spectrum. The boundaries between regions are arbitrary, since no sharp upper or lower limits can be assigned. (H. A. Enge, M. R. Wehr, J. A. Richards, / /ro< MC//ort to Atomic Physics, Addison-Wesley Publishing Company, Inc., Reading, Mass., 1972).

Chapter 20. Somatostatin Daniel F. Veber and Richard Saperstein Merck Sharp Dohme Research Laboratories West Point, Pennsylvania 19486 and Rahway, New Jersey 07065... 

Richard Saperstein, Merck Sharp Dohme Research Laboratories, Rahway, New Jersey... 

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