Serum butyrylcholinesterase

Saxena, A., Raveh, L., Ashani, Y., Doctor, B.P. (1997b). Structure of glycan moieties responsible for the extended circulatory life time of fetal bovine serum acetylcholinesterase and equine serum butyrylcholinesterase. Biochemistry 36 7481-9. 

Eserine blue (250), formed from a reaction of rubreserine with ammonia (315), was reported to exhibit very low potency in a horse serum butyrylcholinesterase assay (314). A later communication (316)suggests total inactivity of these latter two physostigmine derivatives. 

Allon, N., Raveh, L., Gilat, E., Cohen, E., Grunwald, J., and Ashani, Y., Prophylaxis against soman inhalation toxicity in guinea pigs by pretreatment alone with human serum butyrylcholinesterase, Toxicol. Set, 43, 121-128, 1998. 

Garcia, G. et al. Human serum butyrylcholinesterase site-specihc glycan analysis, Glycomics, 2004. Cambridge, MA. 

Genovese, R.F. et al. Evaluation of purihed horse serum butyrylcholinesterase in rats, in Proceedings of the Medical Defense Bioscience Review, Baltimore, MD, 3, 1035, 1993. 

Saxena, A. et al. Human serum butyrylcholinesterase in vitro and in vivo stability, pharmacokinetics, and safety in mice, Chem. Biol. Interact., 157-158, 199, 2005. 

Saxena, A. et al. Gottingen minipigs are protected against sarin vapor by human serum butyrylcholinesterase, in Proceedings of the SthSingapore International Symposium on Protection Against Toxic Substances, Singapore, 2006. 

Sun, W. et al. Safety and pharmacokinetics of human serum butyrylcholinesterase in guinea pigs, Chem-Biol. 

Saxena, A. 2002, Human Serum Butyrylcholinesterase A Future Generation Antidote for Organophosphate Chemical Warfare Agent Toxicity, Proceedings of the Seventh International meeting on cholinesterases, Pucon, Chile. 

Horse serum butyrylcholinesterase isoenzymes have been resolved by electrophoresis on polyacrylamide gel, and the differential reactivity of the various isoenzymes toward butyrylthiocholine has been measured simultaneously in a single gel (C7). The results are shown in Table 5. Only 63 % of the total enzymic activity was found to be associated with the major component (CJ, compared with 80% found by previous investigators (S49). 

W2. Wang, E. I. G., Ionisation of horse serum butyrylcholinesterase. Biochim. Biophys. Acta 198, 236-241 (1970). 

Acuna, M., Eaton, L., Cifucntes, L., and Llop, E. (2003). Genetic variants of serum butyrylcholinesterase in Chilean Mapuche Indians, Am. 7. Phyx. Aiithropoi 121(1), 81-8,5. 

The protective effect from pretreatment of human serum butyrylcholinesterase against inhalation toxicity of lethal doses of soman in guinea pigs has been reported (AUon et al. 

Sanchez-Hernandez J. C., Evaluating reptile exposure to cholinesterase-inhibiting agrochemicals by serum butyrylcholinesterase activity. Environ. Toxicol. Chem., 22, 296-301, 2003. 

Kamal MA, Klein P, Yu QS, Tweedie D, Li Y, Holloway HW, Greig NH (2006) Kinetics of human serum butyrylcholinesterase and its inhibition by a novel experimental Alzheimer therapeutic, bisnorcymserine. J Alzheimers Dis 10 43-51... 

Saxena, A., Chunyuan, L., Doctor, B.R, 2008. Developing procedures for the large-scale purification of human serum butyrylcholinesterase. Protein Express. Rurif. 61,191-196. 

Saxena, A., Sun, W., Fedorko, J.M., et al, 2011. Prophylaxis with human serum butyrylcholinesterase protects guinea pigs exposed to multiple lethal doses of soman or VX. Biochem. Pharmacol. 81, 164-169. 

Myers, T.M., Sun, W., Naik, R.S., et al, 2012. Characterization of human serum butyrylcholinesterase in rhesus monkeys behavioral and physiological effects. Neurotoxicol. Teratol. 34, 323-330. 

Carter, M.D., Crow, B.S., Pantazides, B.G., et al., 2013. Direct quantitation of methyl phosphonate adducts to human serum butyrylcholinesterase by immunomagnetic-UHPLC-MS/MS. Anal. Chem. 85 (22), 11106-11111. Casida, J.E., Quistad, G.B., 2004. Organophosphate toxicology safety aspects of nonacetylcholinesterase secondary targets. Chem. Res. Toxicol. 17 (8), 983-998. 

Doctor, B.P./ Saxena, A., Clark, M.G., et al., 2002. Scavenger protection against organophosphates by human serum butyrylcholinesterase. In The 4th International CB Medical Treatment Symposium, April 28-May 3, 2002, Spiez, Switzerland, Abstract No. 24. 

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