SERS In Vitro Diagnostics of Other Diseases

In addition to pathogen s sensing and cancer diagnostics, SERS was applied to diagnostics of other diseases. This paragraph will introduce some examples. 

The blood serum from type II diabetes, diabetics with complication and healthy volunteers was analysed by SERS (Han et al. 2009). The PCA successfully separated the diabetic patients from healthy volunteers with a sensitivity of 95 %, however, type II diabetes and diabetic complication groups were undistinguishable (Han et al. 2009). Recentiy, the Chen group first employed SERS to detect OxyHb variation in type II diabetic development (Lin et al. 2014). Label-free SERS spectra obtained from blood samples of 49 diabetic patients and 40 healthy volunteers using Ag NPs are compared in Pig. 7.12a. Differences in normalized spectral intensity between diabetic and normal OxyHb are clearly shown in their corresponding difference spectmm (bottom in Pig. 7.12b). The most obvious spectral differences (intensities and positions) can be found in the peaks at 478, 1212, 1312, 

Buoyant silica bubbles were employed as capture substrates in a cholera SERS immunoassay (Schmit et al. 2012). Silica bubbles were silanized and then functionalized with an anti-cholera toxin antibody. Au NPs were used as SERS 

Creatinine is an endogenous degradation product of muscle metabolism and its semm or urine concentration can be the primary indicator in establishing renal function. The SERS spectra of creatinine from human semm down to 0.1 pg ml  

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