Big Chemical Encyclopedia

Chemical substances, components, reactions, process design ...

Articles Figures Tables About

Serotonin transporter neurotransmission

While these functions can be a carried out by a single transporter isoform (e.g., the serotonin transporter, SERT) they may be split into separate processes carried out by distinct transporter subtypes, or in the case of acetylcholine, by a degrading enzyme. Termination of cholinergic neurotransmission is due to acetylcholinesterase which hydrolyses the ester bond to release choline and acetic acid. Reuptake of choline into the nerve cell is afforded by a high affinity transporter (CHT of the SLC5 gene family). [Pg.836]

The activity of 5-HT in the synapse is terminated primarily by its re-uptake into serotonergic terminals 234 Acute and chronic regulation of serotonin transporter function provides means for altering synaptic 5-HT concentrations and neurotransmission 236... [Pg.227]

It is now possible to image not only postsynaptic, but pre-synaptic and intrasynaptic neurotransmission (Fig. 58-5). Presynaptic sites, such as the dopamine transporter and the serotonin transporter the presynaptic dopamine vesicular transporter (VMAT-2) and the acetylcholine transporter extrasynaptic sites such as the enzymes which break down neurotransmitters, e.g. MAO A and MAO B with radioligands that bind to post or pre-synaptic sites, i.e. dopamine competing with radioligands such as UC raclopride (see Fig. 58-9) (PET (Fig. 58-10) can be measured under basal conditions or following drugs which either decrease (e.g. AMPT) or increase (e.g. intravenous amphetamine) intrasynaptic dopamine. [Pg.948]

Blocks serotonin reuptake pump (serotonin transporter), presumably increasing serotonergic neurotransmission... [Pg.13]

In addition to the deficiency of the cholinergic neurotransmission observed in AD and correlated with cognitive function disorders, AD patients also suffer from depression and anxiety. Serotonin transporters (SERT) inhibitors... [Pg.398]

Stress is also involved in the modulation of the immune responses through mechanisms involving the neurotransmitter serotonin. This is a biologically active amine that plays a prominent role in the regulation of processes such as mood, appetite and sleep. During neurotransmission, serotonin is released from neurons into the synaptic cleft between cells. The amount of serotonin available for neurotransmission in the synaptic cleft is regulated largely by the serotonin transporter involved in the reuptake of serotonin after it has been released.23... [Pg.123]

Serotonin, also known as 5-hydroxytryptamine (5-HT) is biosynthesized from tryptophan and is a neurotransmitter. Serotonin plays an important role in many behaviors including sleep, appetite, memory, and mood [52]. People with depressive disorders exhibit low levels of serotonin in the synapses. Protonated serotonin binds to a serotonin reuptake transporter protein, sometimes referred to as the serotonin transporter (SERT) and is then moved to an inward position on the neuron and subsequently released into the cjdoplasm. Selective serotonin reuptake inhibitors (SSRI) bind with high affinity to the serotonin binding site of the transporter. This leads to antidepressant effects by increasing extracellular serotonin levels which in turn enhances serotonin neurotransmission [53]. The SSRI class of antidepressants has fewer side effects than the monoamine oxidase inhibitors. [Pg.199]

Ultimately, the effects of virtually aU existing antidepressants can be traced to the improvement of neurotransmission in the brain by one or more monoamine neurotransmitters, that is serotonin (5-HT, 4), norepinephrine (NE, 5), and dopamine (DA, 6). By blocking monoamine transporters, which remove the neurotransmitter from the synapse and extracellular space by uptake processes, the drugs increase extracellular levels of the transmitter and cause a cascade of intracellular events leading to the desired CNS effect. [Pg.200]


See other pages where Serotonin transporter neurotransmission is mentioned: [Pg.236]    [Pg.237]    [Pg.144]    [Pg.114]    [Pg.385]    [Pg.37]    [Pg.258]    [Pg.112]    [Pg.260]    [Pg.45]    [Pg.93]    [Pg.488]    [Pg.903]    [Pg.144]    [Pg.72]    [Pg.478]    [Pg.535]    [Pg.573]    [Pg.240]    [Pg.11]    [Pg.119]    [Pg.537]    [Pg.157]    [Pg.313]    [Pg.714]    [Pg.577]    [Pg.579]    [Pg.112]    [Pg.260]   
See also in sourсe #XX -- [ Pg.600 ]




SEARCH



Serotonin neurotransmission

Serotonin transport

Serotonin transporter

Serotonin transporter transporters

© 2024 chempedia.info