Serotonin reuptake channel

Serotonin reuptake channel (reduces synaptic serotonin levels)... 

Drugs that may affect cyclosporine include allopurinol, amiodarone, androgens (eg, danazol, methyltestosterone), anticonvulsants (eg, carbamazepine, phenobarbital, phenytoin), azole antifungals (eg, fluconazole, ketoconazole), beta-blockers, bosentan, bromocriptine, calcium channel blockers, colchicine, oral contraceptives, corticosteroids, fluoroquinolones (eg, ciprofloxacin), foscarnet, HMG-CoA reductase inhibitors, imipenem-cilastatin, macrolide antibiotics, methotrexate, metoclopramide, nafcillin, nefazodone, orlistat, potassium-sparing diuretics, probucol, rifamycins (rifampin, rifabutin), serotonin reuptake inhibitors (SSRIs eg, fluoxetine, sertraline),... 

Selective serotonin reuptake inhibitors Bradycardia, Ca " channel blockade... 

Cocaine inhibits the presynaptic reuptake of the neurotransmitters norepinehrine, serotonin, and dopamine at synaptic junctions. This results in increased concentrations in the synaptic cleft. Since norepinephrine acts within the sympathetic nervous system, increased sympathetic stimulation is produced. Physiological effects of this stimulation include tachycardia, vasoconstriction, mydriasis, and hyperthermia.3 CNS stimulation results in increased alertness, diminished appetite, and increased energy. The euphoria or psychological stimulation produced by cocaine is thought to be related to the inhibition of serotonin and dopamine reuptake. Cocaine also acts as a local anesthetic due to its ability to block sodium channels in neuronal cells.3... 

In addition to its other functions BH4 enhances the release of dopamine and serotonin in the rat striatum when administered locally through the dialysis membrane. The enhancement of dopamine release persisted even when dopamine biosynthesis or dopamine reuptake was completely blocked, but it was abolished when hlockers of voltage-dependent Na" " or Ca " " channels were administered with BH4. Further experiments using selective inhibitors of tyrosine, TH, and NOS demonstrated that BH4 stimulates dopamine release directly, independent of its cofactor action on TH and NOS, by acting from the outside of neurons. The exact mechanism is not entirely clear but it has been shown that arginine also induces a concentration-dependent increase of dopamine release in the superfusate of rat striatum slices, and that it is dependent on the presence of BH4. ... 

A. Tricyclic antidepressants are among the widest studied drugs for treatment of painful diabetic neuropathy. It has a documented effect in these patients and meta-analysis has shown a 50% reduction in pain intensity in 30% of patients with diabetic neuropathic pain [28]. Effects are probably due to an inhibition of both 5 HT, norepinephrine and serotonin presynaptic reuptake. Sodium and calcium channel blockade and... 

It is a central nervous system stimulant, preventing reuptake of neurotransmitters like dopamine (see pl69), serotonin (p451), and noradrenaline (p9). This impacts on the pleasure center of the brain, explaining its stimulant effects. It is also a sodium-channel blocker, which causes its anesthetic effects, because it interferes with the transmission of nerve impulses. 

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