Sepsis syndrome, defined

Systemic infections are those that have microorganisms (bacteria, viruses, yeasts, parasites) spread, usually via the bloodstream, beyond the portal of entry or original site of localized infection to multiple compartments of the body. When infections, either localized or systemic, are accompanied by signs and symptoms of a systemic inflammatory response (fever, rapid pulse, increase in white blood cells) the syndrome is called sepsis. Severe sepsis is defined by the additional occurrence of organ failure (either kidney, liver, brain, lungs), and is a potentially fatal condition (mortality around 50%). If there is hypotension not responding on fluid resuscitation it is called septic shock and the mortally is even higher (60-70%). 

GBS remains a serious cause of neonatal infection. GBS disease in the newborn is classified as either early disease, which occurs within 1 week of fife and usually presents as a sepsis syndrome or pneumonia, or late disease, which is defined as that presenting at greater than 1 week of life and that presents most commonly as sepsis or meningitis. 

A UTI is defined as the presence of microorganisms in the urinary tract that caimot he accounted for hy contamination. The organisms present have the potential to invade the tissues of the urinary tract and adjacent structures. Infection may he limited to the growth of bacteria in the urine, which frequently may not produce symptoms. A UTI can present as several syndromes associated with an inflammatory response to microbial invasion and can range from asymptomatic bacteriuria to pyelonephritis with bacteremia or sepsis. 

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