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Sepsis drugs

The Proof of Principle is easy to show since you are likely only to have to show a reduction in blood-bome free soluble TNF. In addition, Eli Lilly has had a sepsis drug approved—in March 2002— and it works by lowering the cytokines interleukin-1 (IL-1) and TNF- which again reinforces the Proof of Principle argument. [Pg.102]

Arterial blood pressure is the product of cardiac output and systemic vascular resistance. Conditions that may lower blood pressure in the critically ill include cardiac failure or hypovolemia (by lowering of cardiac output) and vasodilation (by sepsis, drugs, or neurotrauma). [Pg.462]

Anti-sepsis drug candidates, which are analogues of E5564 (1 8) and (109), have been synthesized. Their lipopolysaccharide LPS-antagonistic activities were measured and found to be more active than the classic glucosamine glucosamine-type disaccharides. The effective dose of (108) for treatment of human whole blood cells was reduced to approximately one fiftieth of that of E5564. ... [Pg.140]

Appropriate empiric anti-infective therapy decreases 28-day mortality compared to inappropriate empiric therapy (24% versus 39%).22 23,30 Additionally, appropriate therapy administered within 1 hour of sepsis recognition also decreases complications and mortality.22-23,30 Empiric anti-infective therapy should include one, two, or three drugs, depending on the site of infection and causative pathogens (Table 79-3). Anti-infective clinical trials in sepsis and septic shock patients are scarce and have not demonstrated differences among agents therefore, factors that determine selection are ... [Pg.1190]

Electrolytes Daily doses based on daily maintenance requirements, renal function, gastrointestinal losses, acid-base status, concomitant drug therapy, nutritional and anabolic status Pa lion I has hyponatremia, hypokalemia, hypomagnesemia, and hypophosphatemia, also has low serum bicarbonate concentration, could be component of metabolic acidosis due to sepsis... [Pg.1503]

We tested this strategy on the enzyme caspase-3, a cysteine-aspartyl protease that is one of the central executioners of apoptosis. Excess apoptosis is attributed to a variety of diseases, from stroke to Alzheimer s Disease to sepsis, making caspase-3 a popular drug target [25]. The enzyme also made an ideal starting point for constructing extenders. It is well characterized both structurally and mechanistically and contains an active site cysteine residue that is irreversibly alkylated by small molecule inhibitors. [Pg.313]

It is used for bacterial infections caused by microorganisms that are sensitive to the drug. These may be abdominal and gynecological infections, sepsis, meningitis, endocarditis, infections of the urinary and respiratory tracts, bones, joints, skin, and soft tissnes. It is widely nsed for pneumonia as well as bacterial meningitis in children, and for post-operational infections complications. Synonyms of this drug are ceftin, zinacef, curoxim, kefox, and many others. [Pg.448]

It is used for peritonitis, sepsis, meningitis, cholangitis, empyema of the gaU bladder, pneumonia, lung abscesses, pyelonephritis, infections of the bones, joints, skin, soft tissues, abdominal and gynecological infections, and for infected wounds and bums. The main synonym of this drug is rocefm. [Pg.457]

It is used for treating sepsis, meningitis, osteomyelitis, periotonitis, pneumonia, pyelonephritis, pyelocystitis, infected wounds, and post-operational purulent complications caused by microorganisms sensitive to the drug. Synonyms of this drug are karmycin, kamaxin, resistomycin, and many others. [Pg.479]

It is used for pyelonephritis, cystitis, pneumonia, pleural empyema, peritonitis, sepsis, meningitis, purulent skin and soft tissue infections, infected wounds, bums, and so on, which are caused by microorganisms that are sensitive to the dmg. Gentamicin is the dmg of choice for severe bacterial infections caused by undetermined stimuli. Synonyms of this drug are garamycin, gentacylin, ribomycin, and many others. [Pg.480]


See other pages where Sepsis drugs is mentioned: [Pg.520]    [Pg.676]    [Pg.676]    [Pg.135]    [Pg.136]    [Pg.365]    [Pg.679]    [Pg.688]    [Pg.1186]    [Pg.1457]    [Pg.209]    [Pg.94]    [Pg.203]    [Pg.1]    [Pg.91]    [Pg.572]    [Pg.576]    [Pg.599]    [Pg.172]    [Pg.359]    [Pg.258]    [Pg.220]    [Pg.265]    [Pg.552]    [Pg.482]    [Pg.486]   
See also in sourсe #XX -- [ Pg.271 , Pg.274 ]




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Sepsis drug therapy

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