Sensing with Nanoparticle Arrays

Van Duyne RP, Haes AJ, McFarland AD. Nanoparticle optics sensing with nanoparticle arrays and Single nanoparticle. Pmc SPIE Int Soc Opt Eng 2003 5223 197-207. 

Owing to their unique (tunable-electronic) properties, semiconductor (quantum dots) nanocrystals have generated considerable interest for optical DNA detection [12], Recent activity has demonstrated the utility of quantum dot nanoparticles for enhanced electrical DNA detection [33, 34, 50], Willner et al. reported on a photoelectrochemical transduction of DNA sensing events in connection with DNA cross-linked CdS nanoparticle arrays [50], The electrostatic binding of the Ru(NH3)63+ electron acceptor to the dsDNA... 

Shengli Zou received B.S. and M.S. degrees in physical chemistry from Shandong University in China and a Ph.D. degree in physical chemistry from Emory University (with Professor Joel M. Bowman) in 2003. He has been a postdoctoral fellow in Professor George C. Schatz s lab at Northwestern University since December 2002. His research interests include the optical properties of nanoparticles and nanoparticle arrays and their applications in biological sensing. He is also interested in the self-assembly of biomolecules. 

Figure 17 (A) Time-dependent frequency changes of a (22)-functionalized Au/quartz crystal upon interaction with (a) The analyte DNA, (23), 2 x 10 M. (b) After treatment of the double-stranded assembly of (22) and (23) with the (24)-functionahzed Au-nanopar-ticles. (c) After treatment of the sensing interface with (23a), 5 x KT M. (d) After treatment of the resulting surface with the (24)-functionalized Au-nanoparticles. (B) Frequency changes of the (22)-functionahzed Au/quartz crystal upon the dendritic amplified sensing of different concentrations of the analyte DNA, (23) (a) Upon the association of the analyte (23) with the sensing (22)-interface (b) Upon the amplification of the primary double-stranded assembly of (22) and (23) with (24)-functionalized Au-nanoparticles (c) Upon the dendritic amphfication of the primary (22)-(23)-(24)-Au-nanoparticle array with the (23)-(22)-Au-nanoparticle probe.

Fig. 27 Sensing mechanism of the nanoparticle-polymer sensor array for cell discrimination. Reprinted with permission from [78]...

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