Semi-rational design

Figure 3.1 Overview of DNA library creation strategies. Random mutagenesis introduces mutations at positions throughout the gene sequence. Semi-rational design randomizes only the specific position(s) of interest. Gene shuffling brings existing sequence diversity from different parental DNA sequences together to form a chimeric library...

The key attribute of flows in micro devices is their laminar character, which stands in contrast to the mostly turbulent flows in macroscopic process equipment. Owing to this feature, micro flows are a priori much more accessible to a model description than macro flows and can be described by first-principle approaches without any further assumptions. In contrast, for the simulation of turbulent flows usually a number of semi-heuristic models are applied, and in many situations it is not clear which description is most adequate for the problem under investigation. As a result, it stands to reason to assume that a rational design of micro reactors... 

Chical, R.A., Doucet, N. and Pelletier, J.N., Semi-rational approaches to engineering enzyme activity combining the benefits of directed evolution and rational design. Curr. Opin. Biotechnol, 2005,16, 378-384. 

Rational design that involve conformation of template-functional monomer complexes employing semi empirical methods69 74... 

Semi-ration ai (saturation mutagenesis at position 221, based on predicted structure) Rationai design based on structurai aiignment with o-... 

Luft S. Beyond directed evolution-semi-rational protein engineering and design. Curr Opin Biotechnol... 

The observation of images of composites may lead to qualitative conclusions only, but it does mean that the existence of certain objects and their reciprocal relations may be confirmed. The quantitative data and their analysis is necessary for rational design of composite materials and for effective determination of the relation between the materials structures and properties. Computer image analysis has been developed over the last 20 years to enable quantitative analysis on the basis of images of any kind. Using a basically similar approach to an image as in manual or semi-automatic methods, the fully automatic approach offers much greater possibilities of quantitative determination of various parameters that characterize the structures of the materials. 

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