Self-sensitized polymers syntheses

Zhou et al. described the synthesis of pH-sensitive biodegradable PUs. They used a novel pH-sensitive macrodiol containing acid-cleavable hydrazone linkers, poly(E-caprolactone)-hydrazone-poly(ethylene glycol)-hydiazone- ly(E-caprolactone) diol (PCL-Hyd-PEG-Hyd-PCL). The macrodiol was used with L-lysine ethyl ester diisocyanate (LDI) and L-lysine-derived tripeptide as chain extender [47]. These PUs could self-assemble into micelles in aqneons solutions. Later, the same research group synthesized pH-sensitive polymers nsing 1,4-bntanediol as chain extenders and suggested its use as antitumor drug carriers [41]. 

Tsvetanov et al. [61] described the trends in modem polymer science in which one of the most important parameters is the synthesis of the multi-stimuli sensitive polymers, which may have different types of response to pH and temperature changes. In addition, the authors showed the importance of the CRPs in the precise control of the macromolecule structure. Incorporating blocks of different chemical natures in controlled positions of these macromolecules lead to self-assembly in aqueous medium resulting in a diversity of stmctures with multiple types of interactions. The review by Kang and colleagues summarizes very well the developments in CRPs, in particular in bioactive surfaces and biomaterials prepared by ATRP [8],... 

Recently, different authors proposed the blend of soy protein with environmentally sensitive polymers to synthesize composite materials with intelligent features, which may result in new potential applications in the biomedical and pharmaceutical fields. Li et al. report the synthesis and self-assembly behavior in aqueous solution of thermally responsive graft copolymer (SPl-g-p(iV-isopropylacrylamide]] of soy protein isolate and N-isopropylacrylamide in aqueous solution by using ammonium persulfate as the initiator and mercaptoacetic acid as the protein unfolding agent (Li et al., 2010]. Alternatively, temperature-sensitive interpenetrating polymer network hydrogels based on... 

Synthesis macrosurfactants, polysoaps, polyelectrolytes as building blocks preparation of spherical, cylindrical, multicompartment, and schizophrenic micelles, polymer vesicles, polyion complexes bottom-up self-assembly stimuli-sensitive colloids... 

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