Self-regulated delivery systems membranes

Taylor Ml, Tanna S, Cockshott S, and Vaitha R. A self-regulated delivery system using unmodified solutes in glucose-sensitive gel membranes. Journal of Pharmacy and Pharmacology 1994 46 (Suppl. 2) 1051a. 

Further development of the self-regulating insulin delivery system has utilized the complex of glycosylated insulin-concanavalin A, which is encapsulated inside a polymer membrane. As glucose penetrates into the system, it activates the release of glycosylated insulin from the complex for a controlled release from the system (Fig. 28). The amount of insulin released is thus self-regulated by the concentration of glucose that has penetrated into the insulin delivery system. 

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