Self-assembly modeling

Fig. 10 (a-f) Hierarchical self-assembly model for chiral rod-like units A curly tape (c ), a twisted ribbon (d ), a fibril (e ) and a fibre (f). Adapted from Aggeli et al. [20], Copyright 2001 National Academy of Sciences, USA... 

Fiamengo R, Crego-Calama M, Reinhoudt DN. Synthetic self-assembled models with biomimetic functions. Curr Opin Chem Biol 2001 5 660-73. 

Vakhrouchev, A.V Simulation of nano-elements interactions and self-assembling . Modeling and Simulation in Materials Science and Engineering. 2006,14, 975-991... 

She, Z., Liu, W., Feng, Q., 2009. Self-assembly model, hepatocytes attachment and inflammatory response for silk fibroin/chitosan scaffolds. Biomed. Mater. 4,045014. 

In this section the in-vitro self-assembly models are briefly described, based upon semi-synthetic chromophores. 

Solution-based analyses of the supramolecular complexation process were carried out by monitoring changes in the absorptitMi spectral feamres as a function of concentration and temperature. Both methods gave data that could be fit to an isodesmic self-assembly model. The complexation constants derived in this way for the concentration- and temperature dependent analyses are 1.76 x 10" M (in DCE at 298 K) and 5.6 x 10 M (in DCE at 293 K and Ct = 125 pM), respectively. 

Zeng Q, KwokY, Kerwin S, Mangold G, Hurley L (1998) Design of new topoisomerase 11 inhibitors based upon a quinobenzoxazine self-assembly model. J Med Chem 41 4273-4278... 

M. Conrad, Quantum molecular computing The self-assembly model. Internal. J. of Quantum Chemistry Quantum Biology Symposium 19 (1992) 125. 

Vebert-Nardin C (2011) Towards biologically active self-assemblies model nucleotide chimeras. Chimia 65 782-786... 

Such differences could play an important role in determining the insertion sites for proteins if their lipid binding sites are specific for certain types of lipids. The self assembly model could also explain how extrinsic subunits of enzymes could be integrated at special sites, since their insertion would be dependent on the presence of their appropriate hydrophobic partners in the membrane. 

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