Selectin-ligand interactions inhibition

Inhibition of the selectin-ligand interactions is an attractive strategy for treating inflammation-related diseases [173,174,175]. As such, sLe has been intensively used as lead structure for development of anti-inflammatory drugs both in industry and academia [176,177,178]. 

Inhibition of Selectin Ligand Interactions Alternatives to Small Molecules. 406... 

Static binding results for physiological binding under shear stress, flow chamber assays are also mentioned. Some representative animal models used to study the inhibition of selectin-ligand interactions in vivo are listed in Section VII. 

Figure 11 Polymers displaying sulfated galactose derivatives are inhibitors of selectin-ligand interactions. The ability of the polymers to inhibit the binding of HL60 cells to immobilized selectins is reported as the concentration required for 50% inhibition (IC50). Polymers were generated using (a) homogeneous conditions or (b) emulsion conditions. For compounds for which IC50 values were not available, the percent inhibition at a particular concentration is reported.

Carbohydrate-mediated cell adhesion is an important event which can be initiated by tissue injury or infection and is involved in metastasis. One such adhesion process is the interaction between the glycoprotein E-selectin and oligosaccharides on the surface of neutrophils (white blood cells). The ligand that E-selectin recognizes is the tetrasaccharide sialyl Lewis X (SLe ). Since SLe competes with white blood cells for binding to E-selectin, thus inhibiting the adhesion process, it may useful as an anti-inflammatoiy and anticancer agent. 

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