See.-Butyl bromide

T) Diethyl sec.-Butylmalonate.—To 700 cc. of absolute alcohol in a 2-1. three-necked, round-bottomed flask equipped with a long, wide-bore reflux condenservs added 35 g. (1.52 gram atoms) of sodium cut in pieces of suitable size. When all the sodium has reacted, the flask is placed on a steam cone and fitted with a mercury-sealed stirrer, a dropping funnel, and a reflux condenser bearing a calcium chloride tube (Note 1). The flask is heated, and 250 g. (1.56 moles) of diethyl malonate is added in a steady stream with stirring. After the ester addition, 210 g. (1.53 moles) of see.-butyl bromide is added at such... 

C4H,Br 109-65-9) sec Bufexamac Bupivacaine Butylscopolammonium bromide Oxybuprocaine Tetracaine see-butyl bromide... 

Phenylaeetonitriie See-Butyl bromide Thionyl chloride Dimethyl sulfate... 

To a solution of 0.30 mol of ethyllithium (note 1) in about 270 ml of diethyl ether (see Chapter II, Exp. 1) v/as added 0.30 mol of methoxyallene at -20°C (see Chapter IV, Exp. 4) at a rate such that the temperature could be kept between -15 and -2Q°C. Fifteen minutes later a mixture of 0.27 mol of >z-butyl bromide and 100 ml of pure, dry HMPT ivas added in 5 min with efficient cooling, so that the temperature of the reaction mixture remained below 0°C. The cooling bath was then removed and the temperature was allowed to rise. After 4 h the brown reaction mixture was poured into 200 ml of ice-water. The aqueous layer was extracted twice with diethyl ether. The combined solutions were washed with concentrated ammonium chloride solution (which had been made slightly alkaline by addition of a few millilitres of aqueous ammonia, note 2) and dried over potassium carbonate. After addition of a small amount (2-5 ml) of... 

To a vigorously stirred suspension of 2 mol of lithium amide in 2 1 of liquid atimonia (see II, Exp. 11) was added in 15 min 1 mol of propargyl alcohol (commercial product, distilled in a partial vacuum before use). Subsequently, 1 mol of butyl bromide was added dropwise in 75 min. After an additional 1.5 h, stirring was stopped and the ammonia was allovied to evaporate. To the solid residue were added 500 ml of ice-water. After the solid mass had dissolved, six extractions with diethyl ether were performed. The (unwashed) combined extracts were dried over magnesium sulfate and then concentrated in a water-pump vacuum. Distillation of the residue through a 40-cm Vigreux column afforded 2-heptyn-l-ol, b.p. 

To a mixture of 0.10 mol of 1-ethoxy-l,2-heptadiene (see this chapter, Exp. 13) and 120 ml of diethyl ether was added 1 g of copper(I) bromide. A solution of butyl magnesium bromide in about 200 ml of diethyl ether, prepared from 0.25 mol of butyl bromide (see Chapter II, Exp. 5) was added in 15 min. The reaction was weakly exothermic and the temperature rose slowly to about 32°C. The mixture was held for an additional 40 min at that temperature, then the black reaction mixture was... 

Ar-(rerr-butyloxycarbonyl)piperidin-4-yl]butyl bromide (C,4H26BrN02 142355-81-5) see Tirofiban hydrochloride -Terr-butyloxycarbonyl-L-threonine... 

C32H37NO4 76811-98-8) see Fexofenadine hydrochloride 4-[4-[4-(hydroxydiphenylmethyl)-l-piperidinyl]-l-oxo-butyl]-a,a-dimcthylbenzeneacetic acid ethyl ester (C34H4[N04 76812-02-7) see Fexofenadine hydrochloride 3a-hydroxy-2p,16p-dipiperidino-5a-androstan-17-one (C2cjH4jN202 13522-14-0) see Pancuronium bromide Vecuronium bromide 9-hydroxyellipticine... 

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