Secretions from stomach drug absorption

As I have already shown, a few years later Bernard Brodie s students at the National Institutes of Health formalized Travell s results by developing their par-tition hypothesis to explain secretion of drugs by the stomach (Fig. 8-7, pp. 296-298). The hypothesis explained the secretion of basic drugs into acid solution, and they turned it around to explain the absorption of acid drugs from acid but not alkaline solutions. Salicylic acid pKa = 3.0) in 0.1 N HCl was absorbed by a rat s stomach to the extent of 61% in an hour. Likewise, acetanilide pKa = 0.3) was absorbed from an acid solution, but barbital and quinine, each having a high pKa, were not absorbed from a similar solution. 

D. Pancreatic Enzyme Replacements Steatorrhea, a condition of decreased fat absorption coupled with an increase in stool fat excretion, results from inadequate pancreatic secretion of lipase. The abnormality of fat absorption can be significantly relieved by oral administration of pancreatic lipase (pancrelipase) obtained from pigs. Pancreatic lipase is inactivated at a pH below 4.0 thus, up to 90% of an administered dose will be destroyed in the stomach, unless the pH is raised with antacids or drugs that reduce acid secretion. 

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