Secretion , drugs

Mahmood, I., Interspecies scaling of renally secreted drugs, Life Sd. 1998, 63, 2356-2371. 

Figure 15.2 Transport proteins involved in the intestinal absorption and the renal and hepatic excretion of drugs. In the intestine, drugs are taken up from the luminal side into enterocytes before the subsequent elimination into blood. In hepatocytes, drugs are taken up from the blood over the basolateral membrane and excreted over the canalicular membrane into bile. In the renal epithelium, drugs undergo secretion (drugs are taken up from the blood and excreted into the urine) or reabsorption (drugs are taken up from the urine and are excreted back into blood). Uptake transporters belonging to the SLC transporter superfamily are shown in red and export pumps...

D) Secreting drugs from the fetal circulation to the maternal circulation... 

Although Sarah admitted to a certain measure of shame connected with her secret drug life, she made a sharp distinction between over-the-counter medications and prescribed medications. At one point, she told me, her family doctor had prescribed Valium because she was a nervous lady ... 

H2 receptors are involved primarily in the regulation of gastric acid secretion. Drugs that selectively block the H2 receptor (referred to simply as H2 antagonists) may help control gastric secretion in conditions such as peptic ulcer these drugs are discussed in Chapter 27. 

According to published reports, Rohypnol was first used to commit date rape in 1993. In 1996, President Clinton signed the Drug-Induced Rape Prevention and Punishment Act. This legislation provides for prison sentences of up to 20 years for anyone possessing a controlled substance with the intent to commit a violent crime, including rape, by secretly drugging someone else. 

Merino G, Alvarez Al, Pulido MM, et al. Breast cancer resistance protein (BCRP/ ABCG2) transports fluoroquinolone antibiotics and affects their oral availability, pharmacokinetics, and milk secretion. Drug Metab Dispos 2006 34 690-695. 

Other organs have the abihty to eliminate drugs or metabolites from the body. The kidney can excrete drugs by glomerular filtration or by such active processes as proximal mbular secretion. Drugs also can be eliminated via bile produced by the liver or air expired by the lungs. 

Pantoflickova D, Martinek J, Blum AL. Safety and potential hazards of long-term inhibition of gastric acid secretion. Drug Safety in press... 

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