Secondary organic solvent-based practical

The enzymatic KR is based on the reaction between the most favored enantiomer of a racemic amine and a suitable acyl donor in an organic solvent. The acylation of amines can also be considered as an aminolysis process, the examples for the KR on primary amines being more common in the literature than the resolution of secondary amines. From fhe hydrolases toolbox, lipases seem to be the most suitable enzymes due to the fact that they scarcely ever hydrolyze an amide bond [184,185], and, therefore, the reaction is practically irreversible. CAL-B has usually shown the best activity and selectivity for fhe resolution of racemic amines [186,187]. 

One of the exciting results to come out of heterogeneous catalysis research since the early 1980s is the discovery and development of catalysts that employ hydrogen peroxide to selectively oxidize organic compounds at low temperatures in the liquid phase. These catalysts are based on titanium, and the important discovery was a way to isolate titanium in framework locations of the inner cavities of zeolites (molecular sieves). Thus, mild oxidations may be run in water or water-soluble solvents. Practicing organic chemists now have a way to catalytically oxidize benzene to phenols alkanes to alcohols and ketones primary alcohols to aldehydes, acids, esters, and acetals secondary alcohols to ketones primary amines to oximes secondary amines to hydroxyl-amines and tertiary amines to amine oxides. 

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