Second-generation computer-assisted

A Second-Generation Computer-Assisted Inhibitor Design Method. ... 

R. L. Desjarlais, G. L. Seibel, and I. D. Kuntz, Jr., in Probing Bioactive Mechanisms, ACS Symposium Series 413, P. S. Magee, D. R. Henry, and J. H. Block, Eds., American Chemical Society, Washington, DC, 1989, pp. 60-69. Second-Generation Computer Assisted Inhibitor Design Method. 

The second stage of this approach is the evaluation of the reaction. This step is the most crucial one in our program, as well as in all other programs of computer-assisted synthesis (16a-16d). The evaluation by the computer is optional. If it is not desirable, the computer proceeds to the generation of all formal possibilities, otherwise the control passes to the EVALUATION module, which discards some solutions. The evaluation is based on the perception of various features of the catalyst and on some rules that we have introduced. These rules concern the two classes of two-electron reactions which will be presented in Section III. The first one contains key reactions of... 

Ihlenfeldt, W.-D. and Gasteiger, J., Computer-Assisted Planning of Organic Syntheses The Second Generation of Programs, Angew. Chem., 34, 2613, 1995. 

Another technique for the generation of via holes is the use of a computer-controlled laser. This procedure is being used in industries that require a wide variety of parts or parts with varied hole patterns. One equipment manufacturer " claims that with a single head system, via diameters from 50 to 350 pm (0.002 to 0.007 in.) can be laser drilled in tapes up to 1.016 mm (0.040 in.) thick at a rate of 30 holes per second. With this system it is very easy to reprogram the computer to generate any hole pattern desired. Care must be taken to assist the removal of the debris generated so that it does not recondense on the surface of the tape-cast material. 

---