Secoiridoids antimicrobial activity

Oleuropein, the secoiridoid responsible for the bitter taste of olives, was studied in vitro for its antimicrobial activity. Recently, it was investigated against Mycoplasma hominis, Mycoplasma fermentas, Mycoplasma pneumoniae, Mycoplasma pirum [87], O. europaea is a plant resistant to microbe and insectan attack. In particular, oleuropein has been shown to inhibit or stop the growth time of a serial of bacteria and microfungi [88]. In general, this compound is used as a food additive. 

In order to explain and confirm the biological activities claimed by the traditional medicine, and to search for new biologically active compounds we studied the antimicrobial, antioxidative, immunomodulatory, antiinflammatory, skin-regenerating and antiviral properties of Fraxinus ornus bark extract and its components. In a parallel detailed phytochemical investigation of the extract we isolated and determined the structures of many hydroxycoumarins, secoiridoid glucosides, caffeoyl esters of phenylethanoid glycosides, lignans and other phenolic compounds. 

Dinda B, Roy Chowdhury D, Mohanta BC (2009) Naturally occurring iridoids, secoiridoids and their bioactivity. An updated review. Part 3. Chem Pharm Bull 57 765-796 Dorman HJD, Deans SG (2000) Antimicrobial agents from plants antibacterial activity of plant volatile oils. J Appl Microbiol 88 308-316... 

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