Phenylethanoid glycosides

Suzuki, N., T. Miyase, and A. Ufno. Phenylethanoid glycosides of Sesamum indicum. Phytochemistry 1993 34(3) 729-731. 

Karioti, A. et al., Acylated flavonoid and phenylethanoid glycosides from Marrubium velutinum. Phytochemistry, 64, 655, 2003. 

Calceolarioside A (phenylethanoid glycoside) Calceolarioside B (phenylethanoid glycoside) (+)-Catechin (= Catechinic acid Catechuic acid) (flavan-3-ol)... 

One of the most widespread examples of phenylethanoid glycosides is verbascoside, also called acteoside, which has been obtained form sources belonging to different plant families. This compound, isolated from Lantana camara (Verbenaceae), was characterised as an inhibitor of rat brain PKC, with an IC50 value of 25 iM. This effect was abolished by adding ATP, which indicated a competitive interaction with the nucleotide. The inhibition was non-competitive with respect to the phosphate acceptor, histones type IIIS in this case, but other kinases, such as PTK from a lymphoma cell line or PKA, were not inhibited. In order to translate the biochemical effect to a related cellular event, the ability of verbascoside to reduce the proliferation of the lymphocytic mouse leukaemia L-1210 cells was examined. This compound showed an IC50 value of 13 pM [32]. 

Ap aggregation inhibitors Acteoside (Phenylethanoid Glycoside) Baicalein Bavachinin... 

S. R. Jensen, Caffeoyl phenylethanoid glycosides in Sanango racemosum andintheGesneriaceae, Phytochemistry, 43 (1996) 777-783. 

ISOLATION, STRUCTURE ELUCIDATION AND BIOACTIVITIES OF PHENYLETHANOID GLYCOSIDES FROM CISTANCHE, FORSYTHIA AND PLANTA GO PLANTS... 

We shall describe the isolation and structure elucidation and HPLC analysis of the phenylethanoid glycosides from several Cistanche plants growing in China, Mongoria, Kazakhstan, Pakistan, Turkey, Bahrain and Qatar, and from Forsythia plants and Plantago plants used as important herbal medicines. 

PHENYLETHANOID GLYCOSIDES FROM CISTANCHE PLANTS Isolation of phenylethanoid glycosides from Cistanche plants... 

Seven phenylethanoid glycosides, acteoside (1), 2-acetylacteoside (2), echinacoside (4), cistanoside A-C (5-7) and cistanoside H (11) were isolated from 50% ethanol extract of C. deserticola [16]. 

Phenylethanoid glycosides from C. tubulosa (Schrenk) G Wight... 

Phenylethanoid glycosides from Cistanche sinensis G Beck in China... 

Two new phenylethanoid glycosides, tentatively named sinenside A (25) and sinen-... 

Table 1. Phenylethanoid Glycosides from Cistanehe plants fer R=OCH3...

HPLC analysis of phenylethanoid glycosides from callus of Cistanche tubulosa, C deserticola and C. phetypaea... 

Structure elucidation of phenylethanoid glycosides were carried out on the basis of spectral analysis and chemical evidences. Assignment of the 13C-NMR chemical shifts of phenylethanoid glycosides were re-examined and shown in Table 2. [24] Two dimensional NMR spectra, such as HfCOSY), H-... 

Table 2.13C-NMR Chemical Shifts of Phenylethanoid Glycosides (in Methanol-rf4)...

Phenylethanoid glycosides consist of phenyethyl glucosyl ether, acyl ester (couma-royl, feruroyl and caffeoyl) and glycosyl groups. The structure of isolated phenylethanoid glycosides was determined or identified by comparison with UV, IR, MS... 

C-NMR chemical shifts of isolated phenylethanoid glycosides were shown in Table 2. At present, two dimensional NMR spectra, such as - H COSY), 1H-13C(HMQC and HMBC) directly afford the importnat structural information Chemical shifts by methylation, glycosylation and acylation suggested the information of substituted carbon positions. 

Studies on the structure elucidation of phenylethanoid glycosides of °C-NMR, the change of chemical shift value were observed. 

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