Search products, typical

Figure 11.2 shows that conventional ATP can be viewed as a bookkeeping function in MPS, which keeps track of uncommitted availability, including planned production and existing inventory, in a database for each finished product. Typical conventional ATP practice formulates a response to an order based on a simple check or straightforward search algorithm. However, for cases involving multiple production and inventory locations, a more complex... 

Typical search products. A majority of the searches done on the PRODBIB file combine a drug name and one or more keywords (Figure 7). Less frequently, a drug name is combined with a field value condition (Figure 8). In addition to these... 

For a given desired product, there are typically numerous reaction alternatives that should be identified and screened. The identification of these reactions is not a straightforward task. The problem is further compounded when the search is limited to environmentally benign cost-effective chemistry. In this context, the following questions should be answered ... 

Collins et al. reported in 1995 that catalysts based on hafnium are desirable for the production of elastomeric polypropylene in that they polymerize propylene to a high molecular weight polymer and are indefinitely stable under typical polymerization conditions [8], Based on the theory that hafnium as a catalytic center leads to a significant increase of molecular weight in propene polymerization compared with the zirconium-based catalyst, Rieger et al. searched for hafnocene systems to obtain polymers with new properties. 

In a typical protocol, the sequence of experiments would be as follows (1) MRM for the parent compound (2) a search for hits using the MRMs included in the biotransformation table and (3) performance of EPI scans on the two most abundant ions found in the MRM scans from the biotransformation tables. An exclusion list is incorporated for those transitions that one wants to eliminate from enhanced product scan data acquisition. 

The drive for the synthesis and characterization of synthetic coordination polymers was catalyzed by work supported and conducted by the U.S. Air Force in a search for materials which exhibited high thermal stabilities. Attempts to prepare highly stable, tractable coordination polymers were disappointing. Typically, only oligomeric products were formed and the monomeric versions were often more stable than the polymeric versions. 

These calculations generally start with a series of known active compounds that are added as search templates (or bait molecules) to a source database and compounds that are identified as similar to these templates based on VS calculations are selected as candidate molecules for experimental evaluation. Activity-oriented VS typically aims at identifying compounds that structurally differ from known templates but have similar activity. This is often done because known active compounds are difficult to develop, not easily chemically accessible (for examples, natural products), or already covered by other patents. In such cases, VS analysis attempts to identify molecular similarity relationships that balance structural and biological similarity in rather different ways, which is often a non-trivial task. 

---