SD rat animal models

Therefore, when it became clearly understood that atrazine is neither estrogenic nor a genotoxic, direct-acting carcinogen - and that the atrazine-associated tumor responses appeared only in female SD rats, a strain with a high, normally occurring incidence of mammary tumors - it became important to study the effect of high doses of atrazine on the SD animal model s own endocrine system and hormonal milieu. 

Flti, 18. Experimental data (symbols) and model simulations (lines) for the blond concentration of iriL-hloropyridmol (TCP) and chlnrpyrifos (CPP) in postnatal day 5 rats given an oral dose of 1 mg CPF/kg of body weight (Dnmoradski et ai. 2004), Values represent the mean SD for four or five animals per time point. 

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