Screening slug flow

Kinetics can be screened in a screw impeller-stirred reactor (SISR) [7] (Figure 9.8). The reactor system comprises a screw impeller that pumps the liquid upwards, and the high exit velocity of the liquid results in an effective foam formation in the top section of the reactor. A slug flow (Chapter 6) is thus established in the monolith channels. Consequently, the liquid and gas are pumped from the lower section to the upper section of the reactor, over and over again. In fact, the concept resembles that of a loop reactor. Cylindrical monoliths are placed in the stator of an SISR (Figure 9.8), and a foam of gas and liquid is forced through the monolith channels by a screw. 

The chip micro reactor ([R 6]) was only one part of a complex serial-screening apparatus [20]. This automated system consists of an autosampler (CTC-HTS Pal system) which introduces the reactant solutions in the chip via capillaries. A pumping system (p-HPLC-CEC System) serves for fluid motion by hydro dynamic-driven flow. A dilution system [Jasco PU-15(5)] is used for slug dilution on-chip. The detection system was a Jasco UV-1575 and analysis was carried out by LC/MS (Agilent 1100 series capLC-Waters Micromass ZQ). All components were on-line and self-configured. 

Use gravel-pack well screen. Inject a slug of brine after every period of interrupted flow. 

Fig. 6.2-52 Simplified flow diagram of dry granulation in the pharmaceutical industry using slugging or roller presses with optional circuit alternatives [Section 13.3, ref. 147] Fig. 6.2-53 a) Granulator for pharmaceutical applications with screen and rod cage,...

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