Screening for new fungicides

For an ideal film fungicide, activity gaps should not exist. Further tests in the cascade are often tests in accordance to EN 152-1 (European Standard EN 152-1, 1988) and tests in dispersion paints based on poly vinylacetate, styrol-acrylate and acrylate. An ideal film fungicide should furthermore show no leaching, a good UV stability and activity against algae. 

In the first screening steps for a new fungicide against basidiomycota, parts of fungal colonies are placed on nutrient agar in which test compounds in different concentrations have been incorporated. After an incubation time of several days, the radial growth of these colonies is compared to biocide-free controls. 

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During the course of screening for new fungicides from microorganisms we encountered two closely related dipeptides with modest activity principally against Phytophthora spp. Herein we describe the isolation and structure elucidation of a novel fungicidal dipeptide,... 

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