Screening automation compound screen platforms

Compound Screen Platforms Workstations and Fully Automated Robotic Systems.189... 

COMPOUND SCREEN PLATFORMS WORKSTATIONS AND FULLY AUTOMATED ROBOTIC SYSTEMS... 

Based on the numbers of daily compound screens, a screening laboratory may choose a workstation or fully automated screen system (Figure 11.3) (Hamilton, 2002). A workstation-based screening platform can be set up quickly and requires less capital funding. The screening throughput with a workstation platform is relatively small—usually 20 to 100 plates per day in 8 hr. A fully automated robotic screen system requires 6 to 12 months for implementation and a minimum investment of... 

This chapter discusses in more detail the operational informatics systems and their integration with compound management and HTS instrumentation. It then covers various aspects of screening data analysis such as statistical methods to define hits, quality considerations, reporting, visualization, and cheminformatics-driven analysis and mining of HTS data. We start from the assumption that the HTS assay has been optimized and miniaturized on an automation platform and that the assay has been validated to deliver robust and reproducible high quality results—the prerequisite of a successful HTS campaign. 

---