Scored Tablets

Where scored tablets are provided, there is often discussion of the suitability of the product for halftablet dosing. This includes data on content uniformity and on the suitability of the finished product for subdivision—e.g., hardness specifications, data on ability to subdivide. 

A prescription requires gr 1/200 of a drug. If a pharmacist has gr 1/100 scored-tablets, how many tablets should be dispensed ... 

The scored Augmentin XR tablets are available for greater convenience for adult patients who have difficulty swallowing. The scored Aygmenf/V XR tablet may be broken in half at score line. The scored tablet is not intended to reduce the dosage of medication taken as stated in the table above, the recommended dose of Augmentin XR is 2 tablets twice daily every 12 hours. 

A scored tablet is a medicine tablet that is designed so that it can be broken into halves or quarters, making it possible to administer a dose that is less than the amount in the tablet. For purposes of these problems, assume that the tablets are scored into quarters. (You can break the tablet into four equal pieces.)... 

The Problem A doctor prescribes 0.375 mg of Digoxin, and the scored tablets that are available contain 0.25 mg each. How many tablets should be administered ... 

Scored tablets and cores for film coating 400 revolutions 1 0... 

Formulations 50 mg scored tablets 20 mL vial containing 100 mg azathioprine... 

Physical attributes of the tablets can affect the calibration process. For example, scored tablets and those... 

Azathioprine, U5P. A/alhioprinc. Imuran. 6- (l-mclhyl-4-nilroimida/ole-5-yl)lliio purine. is prepared from 6-mercaplopurinc and 5-chloro-l-mclhyl-4-nilroimida-zole." It is supplied as 50-mg scored tablets. The injectable... 

Scored tablets may be crushed. Do not crush sustained-release tablets may cut in half. 

Parlodel Patient should be lying down before administering first dose give after food intake (decreases incidence of nausea) obtain pregnancy test if given for infertility Permax Scored tablets may be crushed give without regard to meals... 

Scored tablets may be crushed do not break or crush capsule form. 

A. Oral (Thyro-Block, others), scored tablets (130-mg and 65-mg) of potassium iodide. Formulations of potassium iodide syrups (325 mg KI/5 mL) and oral solutions such as Lugol s solution (5% iodine and 10% Kl) may be found. 

For scored tablets, the product details should include whether the tablets may be broken to obtain half doses, or only to ease the ingestion. 

When tablets may be subdivided and they have a break-mark, the halves have to comply with the requirements on the uniformity of mass of the Ph. Eur. under Subdivision of tablets [2]. Up till now these requirements only apply for scored tablets where subdivision is necessary to meet all the doses that are mentioned in the product information, not for break-marks intended to ease swallowing. There are also requirements proposed on the loss of mass by subdivision and the ease of breaking. In a Dutch study on a representative selection of tablets with a market authorisation only 24 % complied with the requirements on the uniformity of mass of the halves, and 34 % with the proposed standards on ease of subdivision [19]. These results were comparable to those of other studies on patient experiences with the performance of score lines [16, 17]. A so called tablet splitter can be useful (Fig. 37.3), although it does not always give better results than a kitchen knife or breaking by hand. 

Manufacturer Mallinckrodt Inc., Hobart, NY 13788. Each oval, scored tablet contains 800 mg metaxalone... 

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