Scintigraphic assessments

Kirichenko AV, Mason K, Straume M, Teates CD, Rich TA. Nuclear scintigraphic assessment of intestinal dysfunction after combined treatment with 9-amino-20(S)-camptothecin (9-AC) and irradiation. Int JRadiat Oncol Biol Phys 2000 47(4) 1043-1049. 

Jackson, S.L., D. Bush, and A.C. Perkins. 2001. Comparative scintigraphic assessment of the intragastric distribution and residence of cholestyramine, Carbopol 934P and sucralfate. Int J Pharm 212 55. 

Greaves JL, Wilson CG, Rozier A, et al. Scintigraphic assessment of an ophthalmic gelling vehicle in man and rabbit. Curr Eye Res 1990 9 415-420. 

Scintigraphic assessment of liver transplants is helpful (e.g. perfusion, rejection, bile-duct obstruction or bile leakage). (28)... 

Newman, S.P. Scintigraphic assessment of therapeutic aerosols. Criti. Rev. Ther. Drug Carr. Syst 1993, 10, 65-109. 

Pitcairn GR, Lim J, Hollingworth A, et al. Scintigraphic assessment of drag delivery from the ultrahaler dry powder inhaler. J Aerosol Med 1997 10 295-306. 

Wilding, I., Hardy, J., Maccari, M., Ravelli, V., and Davis, S., Scintigraphic and pharmacokinetic assessment of a multiparticulate sustained release formulation of diltiazem, International Journal of Pharmaceutics, Vol. 76, No. 1-2, 1991, pp. 133-143. 

Meseguer, G., Gumy, R., Buri, P, Rozier, A., and Plazonnet, B. (1993), Gamma scintigraphic study of precorneal drainage and assessment of miotic response in rabbits... 

Scintigraphic proof of cirrhosis is based on (i.) enlarged rectangular liver, (2.) reduced and patchy uptake of radioactivity by the hepatic RES ( mottled liver ), (3.) shift in the maximum activity from the right to the left lobe of liver, and (4.) increased uptake by the spleen and bone RES. The recorded scintigraphic findings permit assessment of the course of liver cirrhosis and provide information on focal complications such as .) occlusion of the branches of the portal vein with locally impaired perfusion and (2.) development of hepatocellular carcinoma. 

Introduction of cardiac troponin (cTn) in the early nineties for assessment of myocardial infarct in humans demonstrated that cardiac injury could be monitored with high sensitivity, high specificity, and high practicality—in contrast to all previous biomarkers (Babuin and Jaffe 2005). It is now the preferred biomarker for myocardial infarctions in humans (Alpert et al. 2000) because it stratifies risk, increasing with severity of disease and with life expectancy. In human myocardial infarct, cTn concentration peaks at 18-24 hours and correlates highly with scintigraphic measurements of infarct size made at 72 hours following injury. The increase in blood cTn may persist for a couple of weeks. 

Various scintigraphic and US studies have assessed gastric emptying in patients with untreated CD, and the results of most of them are consistent with a marked delay in gastric emptying that returned to normal after gluten withdrawal (Benini et al. 2001 Bardella et al. 2000). 

Badhwar N, Viswanathan M, O Connell JW, De Marco T, Schreck C, Lee BK, Tseng ZH, Lee RL, Olgin JE, Botviniek EH. Novel scintigraphic parameters to assess left ventricular dyssynchrony predict clinical response in heart failure patients requiring cardiac resynchronization therapy (abstract). J Nuc Med. 2006 47 (Supplement 1) 1P. 

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