Schizophrenia atypical antipsychotics

Kapur S, Remington G (2001) Atypical antipsychotics new directions and challenges in the treatment of schizophrenia. Annu Rev Med 52 503-517... 

George TP, Ziedonis DM, Feingold A, et al Nicotine transdermal patch and atypical antipsychotic medications for smoking cessation in schizophrenia. Am J Psychiatry 157 1835-1842, 2000... 

Changes in perceived physical and mental health status of a schizophrenia patient population following initiation of a conventional or an atypical antipsychotic medication. Poster presented at the American Psychiatric Association Annual Meeting, Toronto, June 1998. 

The advent of novel atypical antipsychotic drugs has sharpened the debate in the UK about the cost burden of schizophrenia to the National Health Service (NHS) and the relative cost-effectiveness of these drugs. Schizophrenia has a prevalence of about 0.5% and a lifetime risk of 1%. Because the disease affects adolescents and has a lifetime course associated with a high degree of hospital and social... 

Although atypical antipsychotic agents may cost several times as much as traditional antipsychotics, drug costs in schizophrenia account for only 1-4% of the total treatment cost (Knapp, 1997). The argument then is that a small increase in drug costs— say to 10% of total cost—may result in disproportionate savings in the highly expensive direct hospital costs, if clinical trial... 

Azorin JM (2000). Acute phase of schizophrenia. Impact of atypical antipsychotics. Int Clin PsychopharmacolX (suppl. 4), 11—14. 

Revicki DA (1999). Pharmacoeconomic studies of atypical antipsychotic drugs for the treatment of schizophrenia. Schizophr Res33 (suppL), slOl-9. 

Stroup, T. S., Lieberman, J. A., McEvoy, J. P. et al. (2006). Effectiveness of olanzapine, quetiapine, risperidone, and ziprasidone in patients with chronic schizophrenia following discontinuation of a previous atypical antipsychotic. Am. J. Psychiatry, 163, 611-22. 

Figure 12.1 Cost of atypical antipsychotic drugs (clozapine and risperidone) in each country/territory for patients with schizophrenia...

Collaborative Working Group on Clinical Trial Evaluations. (1998). Measuring outcome in schizophrenia differences among the atypical antipsychotics. 

Campbell M, Young PI, Bateman DN, Smith JM and Thomas SHL (1999). The use of atypical antipsychotics in the management of schizophrenia. British Journal of Clinical Pharmacology, 4,1, 13-22. 

Clozapine is the prototype of atypical antipsychotic drugs, and it has been used effectively to treat patients with schizophrenia who are unresponsive or intolerant to typical antipsychotics [7]. Clozapine is characterized as atypical by its preferential binding to serotonin (5-HT2) and dopamine D4 receptors (D4) relative to dopamine D2 receptors [8]. A recent body of work also suggests that atypicality may be defined by the rate at which clozapine dissociates from D2 receptors. Specifically, clo-... 

Current treatment of schizophrenia relies on atypical antipsychotic drugs 876... 

The same can be said for treating clients who have schizophrenia and other psychotic disorders. They must be stabilized in order to make progress in therapy. As mentioned in Chapter 2, antipsychotic drugs now allow marked improvement among clients with schizophrenia, and the newer, atypical antipsychotic drugs have fewer side effects so clients are more likely to comply with taking their... 

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