Schizophrenia arachidonic acid

The first is that patients with schizophrenia have a reduced risk of developing inflammatory disorders. The second is that some patients with schizophrenia experience a transient reduction in psychosis when they have a fever. Because metabolism of arachidonic acid is involved both in inflammation and in fever, this led me to consider the possibility that arachidonic acid metabolism abnormalities might be involved in schizophrenia. There is now substantial evidence that this broad statement is true and considerable progress has been made in identifying the precise biochemical abnormalities that may be involved. 

In lipidomics profilings of lipid extracts from postmortem brain tissues with psychoses, including schizophrenia, many lipid abnormalities, including alterations in the levels of NEFA and PC species in gray and white matter and an increase in Cer content in white matter, were found in the patients [105]. Along the same line of findings, elevated arachidonic acid-containing PC species were identified in brain tissue samples of a mouse model of depression [106]. 

---