Scale-down Approach

Schoutens, G. EL, Guit, R. P., Zieleman, G. J., Luyben, K. C. A. M., and Kossen, N. W. F., A Comparative Study of a Fluidised Bed Reactor and a Gas Lift Loop Reactor for the IBE Process Part I. Reactor Design and Scale Down Approach, J. Chem. Tech. Biotechnol., 36 335 (1986a)... 

Zufferey, B. and Stoessel, F. (2007) Safe scale up of chemical reactors using the scale down approach, in 12th International Symposium Loss Prevention and Safety Promotion in the Process Industries, IchemE, Edinburgh. 

Such an approach, based on the experimental simulation of an industrial reactor at laboratory scale, was proposed by Zufferey [11, 12] the scale down approach. In order to simulate the thermal behavior of full-scale equipment at laboratory scale, it is necessary to combine process dynamics and calorimetric techniques. 

Zuflerey, B. (2006) Scale-down Approach Chemical Process Optimisation Using Reaction Calorimetry for the Experimental Simulation of Industrial Reactors Dynamics, EPFL, n°3464, Lausanne. 

Osterhuis, N. M. G., Scale-Up of Bioreactors A Scaled-Down Approach, Ph.D. Thesis. Delft University of Technology, Delft, The Netherlands, 1984. 

The scale-down approach can be applied both in the case of an existing process and for a new process. In the latter case a process design is made for the new process from available process data, experimental evidence, and rules of thumb. Regime analysis is applied to this process design. Based on the results a further sm l-scale research strategy is developed, and eventually changes are made in the process design. 

In reaching our goal of a lab-on-a-chip electrochemical immunosensor system, we have adopted a scale-down approach in which the initial focus was to develop a meso-scale immunosensor system that may be partially fitted with... 

Figure 2.1 Schematic view of the different zones that may appear in a large-scale, fed-batch bioreactor due to deficient mixing. Cells transit continuously through the various zones, leading to complex physiological transient responses. The characterization of such responses is a central theme of the scale-down approach, (a) As the pH control agent in the bioreactor is usually added to...

Purgstaller, A., and A. Moser (1987). Mixing-modelling of a two compartment bioreactor for scale down approaches, Chem. Biochem. Eng., 1(4), 157-161. 

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