Scaffolds of biodegradable block polyurethanes for nerve regeneration

In the 1990s, Schakenraad, Robinson, and colleagues performed systematic research on nerve regeneration using scaffolds based on biodegradable copolymers of DL-lactide and s-caprolactone [10,11]. Based on this work, the first and only commercialized artificial nerve repair scaffold was prepared from the biodegradable copolymers of DL-lactide and s-caprolactone [P(DLLA-s-CL)] and is now used clinically under the trade name Neurolac [12], [Pg.599]

Advances In Polyurethane Biomaterials. http //dx.doi.org/10.1016/B978 0 ( Copyright 2016 Elsevier Ltd, All rights reserved [Pg.599]

Masson s trichrome staining, as well as TEM observation. In this chapter, a systematic investigation and comparison of nerve repair is made using scaffolds made from PUCL-fl/t-PEG, PUCL-ran-PEG, autograft, PCL, silicone tube, and negative control in an SD rat model. [Pg.601]

2 Preparation of poly(ethylene glycol)-diisocyanate prepolymer [Pg.601]

3 Preparation of polycaprolactone and poly(ethylene glycol)-based alternating block polyurethanes [Pg.601]

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