Scaffold monomer

The above reports have produced valuable, large solution-phase Ubraries taking advantage of specific structural features, such as the symmetry of common scaffolds, the wide knowledge accumulated on the reactions used, or the extreme similarity of reactivities of the monomers. Thus, these approaches cannot be generally appUed to a wide diversity of scaffolds, monomers with significandy different reactivities, or difficult reaction steps that produce incomplete reactions or side-products. Consequently, the general synthesis of solution-phase pool libraries is not possible, and for... 

Figure 1 Molecular imprinting of scaffolding monomer having (a) noncovalent bond and (b) covalent bonds between monomer and template, and (c) scaffolding polymers with polymer matrix formation (MF) using interpenetration (IP), cross-linking (C) and aggregation interaction (AI) for matrix formation. P - - C is for polymerization and cross-linking processes and H is for hydrolysis of covalent bonds. E and B stand for extraction and binding of substrate, respectively.

A scaffolding monomer having multi-interaction sites for the target molecule is a general approach that can utilize the principles of both covalent and noncovalent imprinting. Many cases have been described using scaffold multi-mers, which interact with the template via multiple binding interactions and subsequently cross-linked... 

The surface of each layer has two types of single stranded arms (e.g. one 3 — 5 and one 5 — 3 strand) which can bind to other monomers to render 1st-and 2nd-generation dendrimers 25 and 26. Therefore the molecular scaffold grows exponentially with each sequential layer of hybridization. If an oligonucleotide contains a sequence complementary to those at the surface of these networks it should be hybridized. The remaining free sequences from the other type of arms then bind in a standard nucleic acid blot (after they are bound to... 

The polymerization of several different protected monomers was executed with the molybdenum initiator. Two types of norbornene templates were generated as mixtures of diastereomers one class possessed a single saccharide substituent attached through either an endo or exo ester group, and the other was equipped with two carbohydrate residues appended to the bicyclic scaffold... 

A survey of monomer classes, comprehensive up to 1997, has appeared a subset of the more commonly used examples is shown in Figure 2. The NBE derivatives have seen most widespread use (see Section 11.18.5). Functionalized poly(NBE) scaffolds are very widely deployed, owing to the ease with which the monomers (or... 

From a pharmaceutical discovery perspective, it could be fruitful to embark on a library synthesis using cyclic hydroxamic acid templates. There are several reports describing interesting bioactivities for such compounds, particularly as inhibitors of metal-dependent enzymes 48-52 However, only three a-mercapto acid monomers are currently available from commercial sources hence the structural diversity of products that could be easily prepared is limited. Several approaches to introducing additional points of diversity into the benzothiazinone scaffold are currently under investigation. 

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