Scaffold modification oxygenation reactions

Type 1 MTs, currently exclusive for oxygen atoms (OMTs), methylate hydroxyl moieties of phenylpropanoid-based compounds (Fig. 2.3). The phenylpropanoid scaffold is used as a building block for many other types of compounds in the plant. Modification of this basic unit by multiple condensation reactions yields chalcone, flavonoid, isoflavonoid, and pterocarpan skeletons, for example. Flavonoids are ubiquitous in higher plants, where they function as UV protectants,5 defense compounds,6 and stimulators of beneficial mutualistic interactions with microorganisms, insects, and other organisms.7 Isoflavonoid natural products are limited primarily to leguminous plants, where they function as pre-... 

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