Sarpagine-Ajmaline-Picraline Group

Sarpagine-Ajmaline-Picraline Group. Vincamajine and quebrachidine have been found to occur in the leaves and stem bark of Alstonia odontophora,59 normacusine B occurs in Strychnos rubiginosa,ss and vellosimine in Rauwolfia vomitoria.lla R. volkensii contains quaternine, nortetraphyllicine, peraksine, 

CaS04 vii, hv, viii, CF3C03H ix, 3,4,5-trimethoxybenzoic anhy- 

The stems and leaves of Ghanaian Tabernaemontana glandulosa Stapf. contain73 tabernulosine (101), a new base of the picrinine type, which exhibits unusual substitution in the aromatic ring however, details of its structure elucidation are not yet available. 

The leaves of four New Caledonian Rauwolfia species, namely R. balansae ssp. balansae Boiteau, R. balansae ssp. schumanniana var. basicola Boiteau, R. spathulata Boiteau, and R. sevenetii Boiteau, contain vomilenine (102a), JVa-desmethyl-2-dehydrotetraphyllicine (102b), and raucaffrinoline (103), which have previously been encountered in other Rauwolfia species.736 The fourth alkaloid, l-desmethyl-2-dehydro-17-acetylajmaline (104), has been prepared by the oxidation of ajmaline, but has not previously been isolated from a natural source. 

Details have been given of the isolation73c d of lanciferine and of ten other alkaloids from the leaves and twigs of Alstonia lanceolifera S. Moore in the last communication73 this plant is described as A. boulindaensis Boiteau. 

The importance of unequivocally identifying botanical material, and naming it correctly, complete with the authority, is well illustrated in a study of four distinct Ervatamia species, all of which have at some time been named E. orientalis, with consequent inevitable confusion.64 The leaves of E. orientalis (R. Brown) Domin (=Tabernaemontana orientalis R. Brown), from New Guinea, unlike the other 

The presence of vincamajine in Vinca herbacea has been confirmed.44 7 

Raucubaine (125), an alkaloid of Rauwolfia salicifolia Griseb., which is endemic to Cuba, has been described66 as having a novel ring system, but it surely contains the same ring system as quaternoline (126),66c and the two alkaloids may even be identical. 

Koumine (127),670 an alkaloid of Gelsemium elegans Benth. first isolated676 in 1931, is included in this group because it contains a 5,16 bond as well as the novel 7,20 bond its structure was elucidated by the X-ray method. 

Reagents i, HC02H, Ac20 ii, Jones reagent iii, MeOH, NaOH iv, P2S5, PhH v, NaBH4, MeOH 

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Sarpagine-Ajmaline-Picraline Group. Ajmaline and pelirine are among the constituents of the roots of Rauwolfia cambodiana,60 and ajmaline, 12-methoxy-ajmaline, vomalidine, norajmaline, rauvomitine, tetraphyllicine, and ajmaline 17-O-trimethoxybenzoate occur in the roots of R. obscura.61 Vincamajine has been... 

Sarpagine-Ajmaline-Picraline Group. (+)-Quebrachidine (142) is one of the minor alkaloids of the root bark of Cabucala striolata, and of the stem and root bark of C. torulosa, which also contains (-)-vincamajine (143). O-Trimethoxy-cinnamoylvincamajine (144), a known alkaloid, and six new vincamajine derivatives, have been extracted from the aerial parts of Alstonia lanceolifera. Three of the new alkaloids are 10-methoxy-3,4,5-trimethoxycinnamoylvincamajine (145), 10-hydroxy-3,4,5-trimethoxycinnamoylvincamajine (146), and 10-methoxyvinca-majine (147) the other three alkaloids are suspected to be the trimethoxybenzoyl... 

Sarpagine-Ajmaline-Picraline Group. Brief summaries of the chemistry, physico-chemical properties,and the pharmacology " of ajmaline have been published. 

Corynantheine-Heteroyohinbine-Yohimbine Group, and Related Oxindoles Sarpagine-Ajmaline-Picraline Group Strychnine-Akuammicine-Condylocarpine-Ellipticine Group... 

Sarpagine-Ajmaline-Picraline Group. Raucaffrinoline from Rauwolfia caffra has been tentatively assigned a structure corresponding to 21,21-0-dihydro-perakine. 

Sarpagine-Ajmaline-Picraline-Vobasine Group. The roots and stems of Rauwolfia schueli Speg. (R. boliviana Mgf.) have been re-examined,and the ajmaline content has been quantitatively estimated the conclusion is that this plant constitutes one of the richest sources of ajmaline. Ajmaline also occurs in Melodinus balansae Baillon var. paucivenosus, normacusine B occurs in Strych-nos nux vomicai akuammidine in M. celastroides, and pericyclivine and caberine in the aerial parts of Catharanthus ovalis. ... 

Sarpagine-Ajmaline-Picraline-Vobasine Group. The stem bark of Rauwolfia cumminsii Stapf. contains mitoridine and two new alkaloids, Na-demethyl-... 

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