Sarpagine-Ajmaline-Picraline-Vobasine Group

Sarpagine-Ajmaline-Picraline-Vobasine Group. The roots and stems of Rauwolfia schueli Speg. (R. boliviana Mgf.) have been re-examined,and the ajmaline content has been quantitatively estimated the conclusion is that this plant constitutes one of the richest sources of ajmaline. Ajmaline also occurs in Melodinus balansae Baillon var. paucivenosus, normacusine B occurs in Strych-nos nux vomicai akuammidine in M. celastroides, and pericyclivine and caberine in the aerial parts of Catharanthus ovalis. [Pg.170]

Peraksine, norpurpeline (149), dihydronorpurpeline, endolobine (150), purpeline, seredamine, nortetraphyllicine, normacusine B, and desacetyl-picraline have been found in the stem bark of Rauwolfia cumminsii j two minor bases were tentatively identified as O-methylnormacusine B (17-methoxysar-pagan) and its Nb-oxide, and a third, as yet unidentified, is probably also a sarpagan derivative. Sarpagine, normacusine B, purpeline, norpurpeline, norseredamine, nortetraphyllicine, and 10-hydroxynortetraphyllicine occur in R. vomitoria stems an unknown base was provisionally formulated as (151), but the stability of the 7,17-bond in such a structure is very much in doubt. [Pg.171]

Details of the extraction from Pandaca boiteaui Mgf. of methuenine, 19, 20-dehydroervatamine, and ervitsine, whose structure elucidation was reported earlier, have now been published. [Pg.171]

The alkaloid of Rauwolfia reflexa which was initially claimed to be purpeline (159) has now been shown, by examination of its and H n.m.r. spectra, to be the 11-methoxy-isomer (160). It is therefore a new alkaloid, and has been designated rauflexine. The corrected structure for its congener, reilexine, the related secondary alcohol, is therefore (161). [Pg.172]

Yamaguchi, S. Sakai, J. Haginiwa, and A. Kubo, Chem. Pharm. Bull, 1978, 26, 3444. [Pg.172]

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