Sarin oxime therapy

One piece of evidence supporting the efficacy of PAM in sarin toxicity has been the clinical benefit associated with PAM in toxicity due to organophosphorous agrochemicals. However, some experts now doubt whether such a benefit really exists. For example, Peter et al (2006), using meta-analytic techniques, reevaluated the effects of oxime therapy in organophosphate poisoning. Not only did they find no beneficial effects, they also reported possible... 

Nerve agents have caused polyneuropathy in animals only at doses manyfold greater than the LD50 (the dose [D] that is lethal [L] to 50% of the exposed population)—doses that require massive pretreatment and therapy to ensure survival of the animals. Davies et al33 produced polyneuropathy in chickens with sarin only at 60 or more times the LD5q. (The animals were protected with atropine and oxime to permit survival.) Neuropathy was not detected at 8 times the medial lethal dose of soman. Davies s group also detected no polyneuropathy at doses of VX of 45 pmol/kg.34... 

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